ZO-1- and ZO-2-Dependent Integration of Myosin-2 to Epithelial Zonula Adherens
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چکیده
منابع مشابه
ZO-1- and ZO-2-dependent integration of myosin-2 to epithelial zonula adherens.
For the zonula adherens (ZA) to be established by linear arrangement of adherens junctions (AJs) in epithelial sheet cells, critical for the epithelial cell sheet formation and intercellular barrier function, myosin-2 is supposedly integrated into the ZA with the result of overlapping localization of E-cadherin/actin/myosin-2. Here, we immunofluorescently showed that myosin-2 failed to be integ...
متن کاملZO-1/2-dependent integration of myosin-2 to epithelial zonula adherens
For the zonula adherens (ZA) to be established by linear-arrangement of adherens junctions (AJs) in epithelial sheet cells, critical for the epithelial cell sheet formation and intercellular barrier function, myosin-2 is supposedly integrated into the ZA with the result of overlapping localization of E-cadherin/actin/myosin-2. Here we immunofluorescently showed that myosin-2 failed to be integr...
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The structure and function of both adherens (AJ) and tight junctions (TJ) are dependent on the cortical actin cytoskeleton. The Zonula Occludens (ZO)-1 and -2 proteins have contextdependent interactions with both junction types and bind directly to F-actin and other cytoskeletal proteins, suggesting they might regulate cytoskeletal activity at cell junctions. To address this hypothesis, we gene...
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We characterized the sequence and protein interactions of cingulin, an M(r) 140-160-kD phosphoprotein localized on the cytoplasmic surface of epithelial tight junctions (TJ). The derived amino acid sequence of a full-length Xenopus laevis cingulin cDNA shows globular head (residues 1-439) and tail (1,326-1,368) domains and a central alpha-helical rod domain (440-1,325). Sequence analysis, elect...
متن کاملAssociation of ARVCF with zonula occludens (ZO)-1 and ZO-2: binding to PDZ-domain proteins and cell-cell adhesion regulate plasma membrane and nuclear localization of ARVCF.
ARVCF, an armadillo-repeat protein of the p120(ctn) family, associates with classical cadherins and is present in adherens junctions, but its function is poorly understood. Here, we show that ARVCF interacts via a C-terminal PDZ-binding motif with zonula occludens (ZO)-1 and ZO-2. ARVCF and ZO-1 partially colocalize in the vicinity of the apical adhesion complex in polarized epithelial Madin-Da...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2008
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e08-04-0352